منابع مشابه
Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway.
The fission yeast Sty1/Spc1 mitogen-activated protein (MAP) kinase is a member of the eukaryotic stress-activated MAP kinase (SAPK) family. We have identified a protein, Sin1, that interacts with Sty1/Spc1 which is a member of a new evolutionarily conserved gene family. Cells lacking Sin1 display many, but not all, of the phenotypes of cells lacking the Sty1/Spc1 MAP kinase including sterility,...
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The early twentieth-century nationalist discourse in Iran reviled, on the one hand, a Qajar hegemony on account of an exhausted “manifest destiny,” and lauded, on the other, a discourse of masculinity that assumed moral responsibility to protect the imaginary “geobody” of Iran. In this paper I examine how this discourse of patriotism resonates through Mehdi Akhavan-Sales’s poem “This Autumn in ...
متن کاملAn Original Contribution
From University of Cincinnati College of Medicine, Cincinnati, OH. Address Correspondence: Sukdeb Datta, MD, Department of Anesthesiology, University of Cincinnati College of Medicine, PO Box 670531, Cincinnati, OH 45267-0531. E-mail: [email protected] Sources of financial support: University of Cincinnati College of Medicine, Department of Anesthesiology, Cincinnati, OH. Part of this work wa...
متن کاملAn Original Contribution
From Spine Technology and Rehabilitation, and Indiana University School of Medicine, Fort Wayne, IN. Address Correspondence: Joseph D. Fortin, DO, Spine Technology and Rehabilitation, 7230 Engle Road, Suite 210, Fort Wayne, IN 46804. Email: [email protected] Funding: There was no external funding in preparation of this manuscript. The nature, type and frequency of injuries occurring at a national ...
متن کاملCharacterization of Sin1 Isoforms Reveals an mTOR-Dependent and Independent Function of Sin1γ
Sin1 or MAPKAP1 is a key component of mTORC2 signaling complex which is necessary for AKT phosphorylation at the S473 and T450 sites, and also for AKT downstream signaling as well. A number of Sin1 splicing variants have been reported that can produce different Sin1 isoforms due to exon skipping or alternative transcription initiation. In this report, we characterized four Sin1 isoforms, includ...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2013
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc3641